PRF vs. PRP for Hair Loss: Know Your Options

Did you know that over two-thirds of men will experience some degree of hair loss by age 35? 

Hair loss is a real and extremely common concern that can affect your confidence and overall appearance. 

Fortunately, there are options beyond hats and transplants. Non-surgical hair restoration treatments like PRP (platelet-rich plasma) and PRF (platelet-rich fibrin) are gaining popularity for their ability to help men fight back against hair loss. These procedures utilize your own blood’s healing potential to stimulate hair growth and thicken existing hair.

But with two options on the table, you might be wondering: which one is right for me? This blog post will take a deep dive into both PRP and PRF, comparing and contrasting them to help you understand which option might be the best fit for your hair restoration journey. 

Understanding Hair Loss

Before we jump into the world of PRP and PRF, let’s take a quick look at what’s happening under the hood. Hair grows in cycles–a growth phase (anagen), a transition phase (catagen), and a resting phase (telogen). Normally, new hair growth replaces hairs entering the resting phase, keeping your head full.

However, as men age, a hormone called dihydrotestosterone (DHT) can wreak havoc on this cycle. DHT shrinks hair follicles, shortening the growth phase and leading to thinner, finer hairs, eventually resulting in male pattern baldness (androgenetic alopecia). This is the most common cause of hair loss in men.

Other factors can also contribute to hair loss, such as stress, genetics, medical conditions and certain medications. 

Introducing PRP and PRF Hair Restoration

Now that we understand why and how hair loss happens, let’s delve into the science behind two effective treatment options: PRP and PRF. These procedures harness the power of the patient’s own blood to grow fuller, thicker hair. Here’s a quick look at how they work:

First, a small amount of blood is drawn from your arm. This blood then undergoes a specific centrifugation process, separating various components with a special focus on platelets, a type of blood cell known for their role in healing and tissue regeneration. The centrifugation process concentrates these platelets, creating a solution rich in growth factors

The prepared solution is then injected all over the targeted areas of the scalp with tiny needles in a process called microneedling. Once injected, these concentrated platelets release growth factors that awaken dormant hair follicles, combating hair thinning and loss. They also boost collagen production and tissue healing, boosting your skin’s health for even greater benefits.

PRP vs. PRF Treatments: Key Differences

While both PRP and PRF share the core concept of utilizing platelet-rich components to promote hair growth, they differ slightly in their processing techniques and the additional elements they incorporate.

Processing techniques

PRP employs a centrifugation process to concentrate platelets within your blood. Platelets are rich in growth factors, signaling cells to regenerate and repair tissues. During PRP preparation, a small blood sample is drawn and spun in a centrifuge, separating the platelets from red and white blood cells, and an anticoagulant is added to prevent clotting.

A PRF hair loss treatment takes a more holistic approach. A similar blood draw occurs, but the centrifugation process is gentler, resulting in a combination of red blood cells, stem cells, cytokines and other healing factors–meaning that no coagulant additives are necessary. And most importantly, it contains fibrin, a protein that helps blood clot, which allows the formation of a fibrin matrix, a natural scaffolding, along with the concentrated platelets.

Concentration and content

A PRP treatment boasts a higher concentration of platelets due to its more aggressive centrifugation. This translates to a potentially stronger initial stimulation of hair growth.

PRF therapy, on the other hand, contains a slightly lower platelet concentration–but it offers the additional benefit of a fibrin scaffold. This scaffold provides a supportive structure for new cell growth, potentially leading to a more sustained effect.


  • Imagine PRP injections as a potent concentration of growth factors specifically designed to stimulate hair regrowth. 
  • Think of PRF injections as creating a nurturing environment, offering growth factors and a supportive scaffold to promote and sustain new hair growth.

Commonalities Between PRF and PRP

While PRP and PRF take slightly different approaches, they share several key characteristics that make them attractive, effective options for hair restoration:

  • Minimally Invasive: Both PRP and PRF are minimally invasive procedures. This means minimal discomfort and a quicker recovery time compared to traditional hair transplant surgery.
  • Outpatient Setting:  These treatments are typically performed in a doctor’s office or outpatient clinic, allowing you to return to your daily routine shortly after the procedure.
  • Minimal Side Effects:  Like most medical procedures, PRP and PRF may cause some mild, temporary side effects such as discomfort at the injection site, redness, or slight bruising. These typically resolve on their own within a few days.
  • Require Multiple Sessions:  Neither PRP nor PRF is a one-time fix. To achieve optimal hair restoration results, multiple treatment sessions are generally recommended. The specific number of sessions and the recommended spacing will vary depending on your needs and the treatment chosen. 

Selecting Your Champion: Deciding Between PRF and PRP

Having explored the science behind PRP and PRF, we now arrive at a critical juncture: deciding which treatment best suits your needs. Both options hold promise for male hair restoration, but some key factors can influence your choice. Here’s a breakdown to help you navigate this decision:

Severity of hair loss

If you’re experiencing significant thinning or bald patches, PRP’s high concentration of growth factors might be ideal. Its potency could lead to a stronger initial stimulation of hair regrowth in these areas.

Your objectives

If you’re just starting to experience hair thinning and focused on thickening and strengthening what you’ve got? PRF, with its combination of growth factors and the supportive fibrin matrix, might be a good option. The fibrin scaffold can provide a nurturing environment for existing active hair follicles, promoting thicker, healthier growth.

Your preferences

Some patients might have a preference for the presence of the fibrin scaffold offered by PRF. This scaffold provides additional support for new cell growth, potentially leading to a more sustained effect. However, it’s important to note that research on the long-term benefits of PRF compared to PRP is still ongoing.

Consulting with a qualified healthcare professional is paramount in determining the most suitable hair restoration option for you. By carefully considering these factors alongside your doctor’s expertise, you can make an informed decision about whether PRP, PRF or a combination of approaches would be the most effective strategy for your hair restoration journey. 

Boosting Your Results

While PRP and PRF offer promising results for hair restoration, they don’t have to be a solo act in the fight against hair loss.  These treatments can potentially be combined with other hair loss solutions to create a comprehensive approach:

Oral medications

Finasteride is a common medication used to treat male pattern baldness. It can work by blocking the conversion of testosterone to DHT, the hormone that contributes to hair loss. Combining PRP or PRF with finasteride might offer a synergistic effect, addressing hair loss from multiple angles.

Topical medications

Minoxidil is another popular option available in topical solutions. It can stimulate hair growth and potentially work well alongside PRP or PRF treatments.

Taking Control of Your Hair Restoration Journey

So, we’ve explored the science behind PRF and PRP therapy, uncovering their distinct approaches to tackling hair loss. Here’s a quick recap:

  • PRP:  A concentrated dose of growth factors designed to stimulate hair regrowth, potentially ideal for advanced hair loss.
  • PRF:  Offers a combination of growth factors and a supportive fibrin matrix, potentially promoting thicker, healthier hair growth and a more sustained effect.

Remember, the best course of action depends on your unique case. That’s why consulting a qualified healthcare professional is so important–they can assess your hair loss, discuss your goals, and recommend the most suitable treatment plan, whether it’s PRP, PRF, or potentially a combination of treatments, medication, or other hair restoration procedures like hair transplants.  
Don’t wait to take action. Schedule a consultation to discuss your hair loss concerns and explore the path towards a thicker, fuller head of hair.

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